Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway.
Small molecule signaling promotes the communication between bacteria as well as between bacteria and eukaryotes.The opportunistic pathogenic bacterium Legionella pneumophila employs LAI-1 (3-hydroxypentadecane-4-one) for bacterial cell-cell communication.LAI-1 is produced and detected by the Lqs (Legionella quorum sensing) system, which regulates a